The Fighting Irish enter the game with a perfect 7-0 record after their escape of BYU on Saturday in South Bend, 17-14 and are ranked No. 5 in the BCS poll.
The weekly college football show will be on hand at an Oklahoma game for the 28th time. OU ranks No. 3 nationally in the category behind Florida (35 appearances) and Ohio State (30 appearances). "College GameDay" returns to Norman for the first time since 2008, when the show was on campus for OU's 65-21 blowout win over Texas Tech.
Oklahoma is 19-8 in games when GameDay was on hand and 5-1 in games at Owen Field. OU's last appearance was for the Red River Rivalry last year in Dallas.
Kickoff for the Notre Dame vs. Oklahoma game in Norman is set for just after 8 p.m.